Anxiety and attention deficit hyperactivity disorder (ADHD), are among the most frequently diagnosed of all neuropsychiatric disorders. Although many people can be treated with conventional medications, these drugs often have unwanted side-effects and may be diverted for illicit use. NEPRC scientists have made important contributions to our understanding of the biological basis and pharmacological management of anxiety and ADHD, and additional studies have provided new insights into the pathophysiology and treatment of self-injurious behavior (SIB).

Benzodiazepines are the most widely prescribed drugs for the treatment of anxiety, but their clinical effectiveness is limited by significant side-effects, including sedation, memory impairment, and dependence. NEPRC researchers have worked to develop better treatments for anxiety by helping to identify the neuropharmacological mechanisms underlying the anti-anxiety, sedating, and addictive effects of new drugs. Using a sophisticated battery of behavioral models, these studies have provided information that is crucial for developing safer and more broadly effective medications.

Using brain imaging techniques originally developed at NEPRC, our researchers have discovered elevated levels of a key component of the brain dopamine system, the dopamine transporter, in patients with ADHD. This discovery may put the medical community closer to developing more accurate diagnostic tests and better prescribing practices for the disorder. Complementary research has identified polymorphisms in the dopamine transporter gene and is investigating the effects of novel medications in subjects with different levels of behavioral activity in order to develop a more accurate understanding of the biological basis of ADHD.

This is a concept of a person who has his or her own judgement in the waking to the death that brings a sign of hate to the chosen evil that has blood on his hands and don't wish to wash it off, it all relates to a cold rush that's brakes the wind in a sudden flash that has a meaning that signs a dirty taste to there mouth that wish one from another to be silent in within the term of a white dirty lie.

if you justify a difference then there is a term of a black lie, which has a tooth or a bone that crosses its sudden wake like a river that rushes through your blood stream, The internal dirt that figures your actions to confined your wishes of hate or a witch that rides her broom stick that churns her pot of soup that boils at 12 noon that counts her kitchen killer instincts, this is a differences between what you can relate to within the given facts of life.

Nothing but a white lie they say, but does that relate to the truth when we all see a path or route to a change what can aim difference from a person who thinks of them self, to what's is best for them and nothing for no one else, what's ugly and what beautiful, what's the term of love if it don't relate to your inner self, why lie to your self if you don't see a path of your own.

The lost person is the white lie, no hope to spear or no given purpose to there meaning of what's real or fake, hold your stakes, its brakes at eight and signs at nine but everything is calculated within time, as time is a measure, as it can bring pleasure or disgusts to the one who lurks in the mist like a swamp snake with fat finger nails.

Music tells it's truth to people who owe it to them self, confined within your use of communication or information that drives a motive to be dependable, as this gives them self responsibility that would tell the different between a right dirty taste that awakes in your silent, dark, damp, deep, wet, soul like a tunnel that claws with rats that itch for juice or your poison within your inspiration that gives you the right to involve your self in an aspect you have no spoken word of truth. Which states a WHITE or BLACK LIE. They say nothing but a white lie.

Springtail fleas have pale (sometimes spotted, striped or colored) bodies that are divided into several segments measuring about 1/16th of an inch long. They have simple mouth parts which are utilized for piercing and sucking. There are eight simple eyes and four segmented antennae located in the head region.

Springtail fleas get their name owing to a special set of appendages present below the fourth abdominal segment. This appendage, called the furcula, is normally held in place by another special body part (tenaculum) present below the third abdominal segment. On releasing the furcula, the springtail fleas are capable of traveling, jumping or flying through the air nearly 100 times the length of its own body.

The hypogastrura nivicola are also famous for another special suckerlike organ present below the first abdominal segment. This body part allows adhesion, absorption of oxygen and also the ability to drink water from the soil.

Life cycle of the Collembola

Under favorable weather conditions, the hypogastrura nivicola are capable of multiplying very rapidly to the order of thousands per square foot. On drying up of the soil, they need to migrate in search of water.

Springtail fleas generally mate in the spring season and lay hundreds of eggs. They are immune to the cold and can even reproduce in temperatures as low as 40F. The springtail fleas can work their way up to the surface of the snow, earning them the name of ‘snow fleas’.

The eggs develop into nymphs which turn into adulthood in just three weeks provided the weather conditions are right. They have several predators: beetles, ants, centipedes, mites and many other insect-eaters are a threat to snow fleas.

Humans and the hypogastrura nivicola

Springtail fleas do not bite humans and are harmless to most animal groups. However, they migrate during the hot weather from the lawns into the homes. The fact that they are immune to most insecticides makes it difficult to control them.

England's filthiest restaurants should be forced by law to display hygiene ratings, inspectors say. 

Outlets in Wales have had to display food hygiene ratings since 2013, but no such law exists in England.

Inspectors say this results in premises that score lower than three out of five - meaning they must improve hygiene standards - failing to display ratings.

The British Hospitality Association (BHA) said it believed the display of hygiene notices should be voluntary.

The BBC's Inside Out team filmed a hygiene inspection in Leicester, where evidence of mouse and rat droppings, dirty dishes and floors and mouldy kitchen surfaces was uncovered. Andrew Wood, from the inspection team, said: "I find it frustrating [that ratings are not displayed].

"Members of the public are not always able to check the ratings online so in a way they are going into these places blind.

"It must also be frustrating for businesses that have achieved good ratings." 

Leicester City Council's food safety team manager, David Barclay Rhodes, said: "At the moment, I can walk along any street in England and see stickers with five, four and three ratings which mean they are satisfactory or better, but I never see the bad ones. Assistant city mayor of Leicester, Susan Waddington, said: "We feel it would be better if it were compulsory for the rating to be displayed on the window quite clearly and inside the restaurant.

"That way, customers can make a choice and the people that run the businesses have a motivation to improve where hygiene standards are not high enough."

She added: "I think owners would be motivated to push up standards. The BHA said it believed display of the ratings would soon become mandatory in England.

However, it criticised the ratings for a lack of consistency and said it would only support their mandatory display "if an effective and independent appeals process is put into place. 

This term is subjected to a meaning based on a description of a negative disapproval from a justify use of disgusting words, nasty is the term that is calculated to the way it should be addressed, its an attack from another person who has hate or disadvantage to the way in life. Expression is a use of communication that is adapted around different sources of information that would aim to help complete a given purpose to criticize the internal concept of building relations between another person who has hate to help you address information that would aim punishment.

A Strong reason to use a path to uphold a given target that is of negative impact that would affected a person life, a term of death to the soul of one that has the vision to conclude further to be blamed through life that sees a person turn to the dark side of life.

No hope or a dead end that fogs the dark mist with a cold draft that brakes like ice on a frozen lake that swamp's the muck of dirt and grim green slime, no vision but a dark door that can't open with damp that claws the internal frame of the inside that eats like cockroaches through your guts.

Enter the house of lost trust that hears a silent voice that awakes your internal soul like a cry from a child that's lost in the trace of the forgotten in a planet that surrounds million of despaired for the open soul that one has to uphold.

Three knocks on the door and it cracks like shattered glass, an awaken mind that transforms from internal brain functions to a skull of death that has cross bones attached with fire and fly's spraying out of its mouth like a mist of green spiritual cloud, tracks the one who condemns death to the soul who forgives the danger of the dark night that is trapped in a cave of skulls that brakes a sad cry from the internal soul that rages with fire. (Condemn)

Bacterial meningitis is very serious and can be deadly. Death can occur in as little as a few hours. Most people recover from meningitis. However, permanent disabilities (such as brain damage, hearing loss, and learning disabilities) can result from the infection.
There are several types of bacteria that can cause meningitis. Leading causes in the United States include

• Streptococcus pneumoniae
• Group B Streptococcus
• Neisseria meningitidis
• Haemophilus influenzae
• Listeria monocytogenes

On average, bacterial meningitis caused about 4,100 cases and 500 deaths in the United States each year between 2003 and 2007
These bacteria can also be associated with another serious illness, Sepsis is the body’s overwhelming and life-threatening response to infection that can cause tissue damage, organ failure, and death.

Causes

Common causes of bacterial meningitis vary by age group:

• Newborns: Group B Streptococcus, Streptococcus pneumoniae, Listeria monocytogenes, Escherichia coli
• Babies and children: Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae type b (Hib), group B Streptococcus
• Teens and young adults: Neisseria meningitidis, Streptococcus pneumoniae
• Older adults: Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae type b (Hib), group B Streptococcus, Listeria monocytogenes

Risk Factors

Certain people are at increased risk for bacterial meningitis. Some risk factors include:

• Age
  • Babies are at increased risk for bacterial meningitis compared to people in other age groups. However, people of any age can develop bacterial meningitis. See section above for which bacteria more commonly affect which age groups.
• Community setting
  • Infectious diseases tend to spread where large groups of people gather together. College campuses have reported outbreaks of meningococcal disease, caused by N. meningitidis.
• Certain medical conditions
  • There are certain medical conditions, medications, and surgical procedures that put people at increased risk for meningitis.
• Working with meningitis-causing pathogens
  • Microbiologists routinely exposed to meningitis-causing bacteria are at increased risk for meningitis.
• Travel

Charlie sheen is being accused of sodomizing a then 13-year-old Corey Haim on the set of the movie 'Lucas.'

According to the national enquirer a now deceased Haim had told others about how he was allegedly raped as a minor by Sheen, who was 19 at the time, while filming the 1986 movie. 

Former actor Dominick Brascia claims Haim disclosed to him what happened between him and Sheen. Brascia went on the record about what he says Haim told him before he died in 2010 at 38-years-old. 

'Haim told me he had sex with Sheen when they filmed 'Lucas,' Brascia told the Enquirer. 'He told me they smoked pot and had sex. He said they had anal sex. Haim said after it happened Sheen became very cold and rejected him. When Corey wanted to fool around again, Charlie was not interested.'

Meanwhile on Wednesday, Sheen emerged from his parents Martin and Janet Sheen's home looking defiant while smoking a cigarette in the face of the bombshell allegations against him. The magazine also says that Lost Boys actor's closest friend, Corey Feldman, alluded to the alleged incident in his book 'Coreyography: A Memoir.' 

'At some point during the filming [of 'Lucas,' Haim] explained an adult male convinced him it was perfectly normal for older men and younger boys in the business to have sexual relations, that it was ''what all guys do,'' Feldman wrote.

'So they walked off to a secluded area between two trailers during a lunch break for the cast and crew,' continued Feldman,' and Haim, innocent and ambitious as he was, allowed himself to be sodomized.' Feldman never named Sheen as the man in the incident. 

In 2011, according to the Enquirer, when Feldman was asked about Sheen he said: 'I'm not a huge fan of Charlie Sheen…especially the way he's affected other people that I know.' Tellingly, Feldman also said Haim 'fought for his entire life to recover from those early experiences and to get his life together.'

And, just last week, on the Today Show, Feldman said a report coming from the National Enquirer was to be expected. 'They cover it up. They protect it. I know of a friend of mine that actually went and spoke to a reporter and gave all the information and they were -- the day before I launched my campaign, they were supposed to put out a story in the [National] Enquirer.'  

'I believe there's a lot of darkness in Hollywood right now, and I believe it's been there for quite some time,' said Feldman. 'It's going to continue unraveling. This is just the beginning, it's just the tip of the iceberg.