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Wednesday, 11 October 2017
In the development of new drugs, taking something from nature and modifying it has been a successful tactic employed by medicinal chemists for years. Now, with the help of nanotechnology, researchers are turning once-discarded drug candidates into usable drugs.
An estimated 40% of clinical approved drugs fall into the category where either the natural compound itself or a modified version is the approved drug. These include statins (found in bacterial secretions) used to lower cholesterol, quinines (found in cinchona trees) as anti-malarials and paclitaxel (found in yew trees) as anti-cancer medication.
Many of these natural products are toxins produced by plants or animals as a form of defence. And scorpion venom has been gaining interest as a source of new drugs. It contains a mixture of biological chemicals called peptides, some of which are known to trigger cell death by forming pores in biological membranes. Cell death can be useful if we are able to target, say, tumour cells to auto-destruct.
These toxins can have very potent effects. For instance, one particular small peptide, known as TsAP-1, isolated from the Brazilian yellow scorpion (Tityus serrulatus), has both anti- microbial a And anti cancer properties
However, harnessing this kind of power for clinical good has so far been challenging because these toxins kill both tumours and healthy cells. One method to control such toxicity is through using nanotechnology to build specific anti drug delivery vehicles If successful, the toxic drug is released to kill only unwanted tissues in a body.
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Tuesday, 10 October 2017
A 25-year-old Romanian has been jailed after raping his pregnant 'wife' who he had moved to Britain with.
The man, of Romany gypsy background, illegally married the girl in their native country before settling in Essex.
He was imprisoned for six years after admitting having sex with a child under the age of 13.
The man, who cannot be named for legal reasons, has said he wants to 'reignite' the relationship when he has served his prison sentence.
The girl is understood to have returned to Romania and is just weeks away from giving birth, the court heard.
The man's lawyer said he had got 'caught up' in what was a 'widespread practice' and 'tradition' and claimed his 'upbringing' had landed him in court. Jamie Sawyer, prosecuting, said the age of consent in Romania is 16 - the same as in the UK.
He said: '[The couple] met in Romania and in the victim's view, no one complained about the age gap between them. She has gone back to Romania, and the defendant says how he has a wish to reignite that relationship when he is able.'
Their illegal marriage was uncovered by police on April 7 this year when their car was stopped at a car wash in Epping while they and two other children were in it.
Detectives later searched their home and found a small room with a double bed the Romanian man and the girl shared.
Laura Kenyon, defending, told the court the marriage was an 'exceptional' case with very 'unusual circumstances'.
She said: 'There is no grooming, exploitation, force or coercion in this case. This was consent within a marriage, albeit an unlawful marriage.
'This is a widespread practice, an ancient custom that is still used today. The marriage of a young girl and older man is not an extraordinary event in their culture.
'He is following that tradition and is caught up in it.'
Chelmsford Crown Court was told Romany gypsies are 'badly marginalised' in Romania and the defendant's 'upbringing' had landed him in court.
But the man was jailed for six years after admitting having sex with a child under the age of 13.
Sentencing, Judge Patricia Lynch said: 'The issue here is the age of consent and age of lawful marriage in Romania is the same as in this country – it is 16 years of age.
'Sexual activity with children is against the law and we are dealing with a 12-year-old child, no matter what the customs are in another land. She is a child expecting a child I am told in a few short weeks and I am told she will not have an education in Romania.
'This is not a case of informed consent. Children need to be protected from others and from their selves.'
The man was given full credit for admitting statutory rape and was jailed for six years.
He will also spend 10 years on the sex offenders register.
Monday, 9 October 2017
The Prime Minister will publish an analysis showing huge disparities in employment rates and school attainment between white people and those from ethnic minority backgrounds.
She will launch a massive database – the first of its kind in the world – covering 130 areas of life across health, education, employment and criminal justice, all broken down by race.
Mrs May has ordered a review of school exclusions after the audit revealed that some black children were three times as likely to be excluded or suspended as white British ones. The figures show that poorer white children tend to do worse in tests at junior schools, and that black people are less likely to own a house and more likely to be found guilty in court.
The Conservative leader will use the statistics to challenge society to ‘explain or change’ disparities in how people from different backgrounds are treated.
She will tell Whitehall, businesses, police and other institutions that they have ‘nowhere to hide’ and must help ensure race is never a barrier to people achieving their goals in life.
On a visit to a school in South London, Mrs May told sixth form students: ‘What I hope this audit will bring is a change in attitude so that everyone is treated equally, no matter what their background, and this is never a barrier to getting on in life.
‘By bringing this information together in one place for the first time it will shine a light on the issues we are facing. We must now work together as a society to find solutions.’
Mrs May will launch the new Ethnicity Facts and Figures website today, saying she hopes it will become an ‘essential resource in the battle to defeat ethnic injustice. Among the findings were that the 8 per cent unemployment rate for black, Asian and minority ethnic people is nearly double that of white British adults.
Mrs May will say: ‘People who have lived with discrimination don’t need a government audit to make them aware of the scale of the challenge.
‘But this audit means that for society as a whole – for Government, for our public services – there is nowhere to hide.
‘These issues are now out in the open. And the message is very simple: if these disparities cannot be explained then they must be changed.
‘Britain has come a long way in my lifetime in spreading equality and opportunity. But the data we are publishing today will provide the definitive evidence of how far we must still go in order to truly build a country that works for everyone. The Ministry of Justice will put in place recommendations from the recent Lammy Review, including performance indicators for prisons to assess how prisoners of different races are treated.
The ministry will also be made to adopt an ‘explain or change approach’ to ethnic disparities and publish all data held on ethnicity by default. Prison chiefs will be urged to improve the recruitment, retention and progress of minority staff.
In education, an external review will look at cases of children excluded from school, with a focus on ethnic groups disproportionately likely to be suspended or expelled.
In 2015/16, Irish traveller pupils were the most likely to be excluded, with a rate of 0.49 per cent. They were followed by gipsy and Roma children (0.33 per cent). Black Caribbean pupils – at a rate of 0.29 per cent – were permanently excluded at three times the rate of white British pupils.
Sunday, 8 October 2017
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