What is Parkinson’s disease?
Parkinson’s disease is a chronic (long-term) neurological condition. It is progressive and symptoms worsen over time. It is named after Dr James Parkinson who first described the condition in 1817.
People with Parkinson’s disease experience a loss of nerve cells in the part of their brains responsible for controlling voluntary movements. This part of the brain is called the substantia nigra (a small cluster of cells deep in the centre of the brain within an area called the basal ganglia). The nerve cells in the substantia nigra usually produce a chemical called dopamine which helps transmit messages from the brain to the rest of the body via the central nervous system (the brain and spinal cord). As these cells are lost, people with Parkinson’s disease experience a loss of dopamine and the messages controlling movement stop being transmitted efficiently.
Parkinson’s disease is more common as people get older but it can affect younger adults. Men tend to be affected in slightly higher numbers than women.
What causes Parkinson’s disease?
We do not know what causes Parkinson’s disease. There is some evidence to suggest that there is a genetic factor which increases the risk of Parkinson’s disease within some families. Also, there might be an increased risk if people have come into contact with a particular toxin (poison) or toxins found in the environment via pesticides and other chemicals used in agriculture. The specific toxin or toxins have not yet been identified but there is ongoing research into this possible cause.
What are the symptoms?
Each person is affected differently by Parkinson’s disease and no two people will experience exactly the same symptoms. The impact of Parkinson’s disease can be unpredictable and it is common for people to have good days and bad days.
The main symptoms of Parkinson’s disease are:
- tremor (involuntary trembling or shaking movements; the most common symptom)
- rigidity (stiffness)
- slowness of movement (bradykinesia)
- balance problems
- problems with posture (particularly a tendency to stoop forwards)
Other possible symptoms include difficulty initiating movement (for example, when getting up from a chair), a shuffling gait when walking, and freezing when trying to move (especially in confined spaces such as doorways). People might experience a loss of facial expression, speech problems (softened voice, slurred speech), swallowing problems, bowel and bladder problems, difficulties at night (discomfort in bed, cramps, disturbed sleep pattern) and tiredness during the day. Skin can become greasy and people might experience excessive sweating. Sexual problems are common. People often experience depression and anxiety. Another common symptom is small handwriting (micrographia).
Other less common symptoms can include pain and memory problems.