AFM is one of a number of conditions that can result in neurologic illness with limb weakness. Such illnesses can result from a variety of causes, including viral infections, environmental toxins, genetic disorders and others. Despite extensive laboratory testing, a cause for AFM is unable to be identified.
AFM is characterized by:
- Acute onset of focal limb weakness
- An MRI showing a spinal cord lesion largely restricted to gray matter and spanning one or more spinal segments
- Cerebrospinal fluid (CSF) with pleocytosis (WBC >5 cells/mm3)
In 2015, 16 people from 12 states had confirmed AFM. In 2014, a total of 115 people from 34 states were reported to have confirmed AFM.
Transmission
AFM has numerous suspect etiologies, but a cause for AFM is unable to be identified. Suspected viruses identified in AFM patients include:
AFM has numerous suspect etiologies, but a cause for AFM is unable to be identified. Suspected viruses identified in AFM patients include:
- Enteroviruses (polio and non-polio)
- West Nile virus (WNV) and viruses in the same family as WNV, specifically Japanese encephalitis virus and Saint Louis encephalitis virus
- Herpesviruses, such as cytomegalovirus and Epstein-Barr virus
- Adenoviruses
Lab Tests & Specimen Info Isolation Procedures
Standard precautions are recommended in healthcare settings.
Prevention for Patients
Persons can help protect themselves from known causes of AFM by:
Persons can help protect themselves from known causes of AFM by:
- Being up to date on all recommended vaccinations, including poliovirus
- Washing hands often with soap and water
- Avoiding close contact with sick people
- Cleaning surfaces with a disinfectant, especially those that a sick person has touched
- Protecting from mosquito-borne viruses such as West Nile virus
Public Health Actions
Public health can provide targeted guidance for the workup and therapies of a suspect AFM case.
Public health can provide targeted guidance for the workup and therapies of a suspect AFM case.
Public health will conduct an epidemiological investigation on a case or suspect case.
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