Signs and symptoms
Chronic mucocutaneous candidiasis
Findings reveal disfiguring lesions of the face, scalp, hands, and nails. Chronic mucocutaneous candidiasis is occasionally associated with oral thrush and vitiligo.
Oropharyngeal candidiasis
Individuals with oropharyngeal candidiasis (OPC) usually have a history of HIV infection, wear dentures, have diabetes mellitus, or have been exposed to broad-spectrum antibiotics or inhaled steroids. Although patients are frequently asymptomatic, when symptoms do occur, they can include the following:
- Sore and painful mouth
- Burning mouth or tongue
- Dysphagia
- Thick, whitish patches on the oral mucosa
Physical examination reveals a diffuse erythema and white patches that appear on the surfaces of the buccal mucosa, throat, tongue, and gums.
The following are the 5 types of OPC:
- Membranous candidiasis - One of the most common types; characterized by creamy-white, curdlike patches on the mucosal surfaces
- Chronic atrophic candidiasis (denture stomatitis) - Also thought to be one of the most common forms of the disease; presenting signs and symptoms include chronic erythema and edema of the portion of the palate that comes into contact with dentures
- Erythematous candidiasis - Associated with an erythematous patch on the hard and soft palates
- Angular cheilitis - Inflammatory reaction characterized by soreness, erythema, and fissuring at the corners of the mouth
- Mixed - A combination of any of the above types is possible
Esophageal candidiasis
Patients with esophageal candidiasis may be asymptomatic or may have 1 or more of the following symptoms:
- Normal oral mucosa (>50% of patients)
- Dysphagia
- Odynophagia
- Retrosternal pain
- Epigastric pain
- Nausea and vomiting
Physical examination almost always reveals oral candidiasis.
Nonesophageal gastrointestinal candidiasis
The following symptoms may be present:
- Epigastric pain
- Nausea and vomiting
- Abdominal pain
- Fever and chills
- Abdominal mass (in some cases)
Genitourinary tract candidiasis
The types of genitourinary tract candidiasis are as follows:
- Vulvovaginal candidiasis (VVC) - Erythematous vagina and labia; a thick, curdlike discharge; and a normal cervix upon speculum examination
- Candida balanitis - Penile pruritus and whitish patches on the penis
- Candida cystitis - Many patients are asymptomatic, but bladder invasion may result in frequency, urgency, dysuria, hematuria, and suprapubic pain
- Asymptomatic candiduria - Most catheterized patients with persistent candiduria are asymptomatic
- Ascending pyelonephritis - Flank pain, abdominal cramps, nausea, vomiting, fever, chills and hematuria
- Fungal balls - Intermittent urinary tract obstruction with subsequent anuria and ensuing renal insufficiency
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